Coffee paradox and stroke

Specialized journal (electronic version) of this month nutritional neuroscience, studies that have examined the association between coffee consumption and the risk of stroke had been reported. (Nutr Neurosci. 2015 Jun 22.) Coffee and green tea, health maintenance and lifestyle-related disease prevention effect by ingestion of black tea has been shown. One polyphenol contained in coffee, antioxidant effect of chlorogenic acid, It is believed that effect through the action, such as green tea catechin. In this study, About association between intake and stroke risk of coffee, verification of the cohort study was conducted. In particular, From; (NHANES III 1988-1994), the US National Health and Nutrition Examination Survey Intended for more than 17 years of age, Correlation between the intake and risk of stroke of coffee has been studied. Among the subjects 33,994 people, Both of the data of the intake and stroke of coffee to those obtained, it was 19,994 people. Intake of coffee, It is between 0 cup of 20 cups, Subjects diagnosed with stroke, 644 was (3.2%) name. First, Intake of coffee, Age and gender, differences by race was recognized. (P <0.001) Then, In the three or more cups per day of intake group of coffee, Heart failure, diabetes, the prevalence of hypertension is significantly lower, Hypercholesterolemia significantly higher, Correlation that was observed. (P <0.001) In the consumer of coffee has also been observed smoking. (P <0.0001) The results of multivariate analysis, Intake of 3 or more cups per day of coffee, Independently of other factors, Reducing significantly the risk of stroke was found. In healthy subjects, By 3 or more cups of coffee intake of, and reduction of 56% of stroke risk, (OR 0.44, 95% CI 0.22-0.87, P <0.02) Reduction of 22% of vascular disease risk (OR 0.78, 95% CI 0.58-1.07, P ≈ 0.12) It has become. From the above data, In the 1st 3 or more cups of coffee intake person, Despite the smoking history, Reduction in stroke risk is suggested. The title of this paper, The coffee paradox coffee paradox in stroke Expression has been used that. This, despite the risk of stroke as smoking, Stroke we are pointing that has been lowered by the intake of coffee. (In similar expressions, it is French paradox is well known.) In DHC, we have a variety of tea, herbal tea, coffee, decaffeinated beverages and commercialized. By previous epidemiological studies, reduction of lifestyle-related diseases risk by ingestion of coffee has been known. For example, ingestion of type 2 diabetes risk reduction due to coffee, reduced risk of stroke, lowering depression risk, decrease in liver cancer risk, and suppressing reduction of cognitive function. The coffee contains a chlorogenic acid is one of phytochemicals, lifestyle diseases preventive effect via anti-oxidative effects has been suggested. (As a major component other than caffeine in coffee, ferulic acid (ferulic acid), caffeic acid (caffeic acid,), chlorogenic acid (chlorogenic acid) are known, it indicates any antioxidant effect. Of these chlorogenic acid is relatively abundant in the middle.) This epidemiological studies and clinical trials of up to, improvement of hypertension, reduction of cardiovascular disease (atherosclerotic disease) risk, such as an anti-cancer effect has been reported. For example, research such as the following have been known. Total mortality and cardiovascular disease risk reduction effect of coffee consumption: meta-analysis Relationship between the intake and urinary cancer of coffee @ meta-analysis The prostate cancer risk reduction effect of the intake of coffee @ meta-analysis And liver cancer risk reduction effect of coffee Association between intake and prostate cancer risk of coffee The oropharyngeal cancer risk reduction effect of the intake of coffee Relationship of chocolate and coffee intake and liver function @ HIV-HCV co-infected persons Intake of coffee to suppress depression risk women